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Uterobrush (Endometrial Sampling)

Uterobrush is a minimally invasive method in which a small sterile brush is introduced into the uterine cavity to collect a sample of the lining (endometrium). 

The sample is sent for cytological analysis to detect suspected changes, including endometrial hyperplasia and carcinoma.

Page Overview

What is the Uterobrush procedure?

Uterobrush is a method of direct intrauterine sampling: a brush is introduced through the cervix into the uterine cavity and, by rotation, collects cells of the lining (endometrium) for cytological analysis.

Note: It is used to detect endometrial abnormalities (especially hyperplasia and cancer), while some changes such as polyps may require additional diagnostics (e.g. hysteroscopy) at the doctor's discretion.

What is assessed?

The aim is to obtain information about the state of the endometrium in situations where the following are present:

  • abnormal bleeding
  • a thickened endometrium on ultrasound
  • suspicion of endometrial hyperplasia or cancer (as part of the work-up)

When is Uterobrush recommended?

When your gynaecologist wants to take a sample of cells from the uterus quickly and minimally invasively. The most common indications in practice: 

Abnormal bleeding

  • heavy, prolonged or irregular bleeding
  • bleeding between periods
  • bleeding after intercourse (with the necessary gynaecological assessment)

Menopause and postmenopause

  • bleeding in menopause and postmenopause
  • suspicion of endometrial changes (e.g. a thickened endometrium on ultrasound)
  • when an endometrial sample needs to be obtained without hospitalisation (as indicated)
A quick decision: If you have bleeding after menopause, get in touch as soon as possible - this is always a reason for prompt diagnostic work-up.

What does the procedure - taking an endometrial sample - look like?

1. Conversation and indication

The doctor talks with you about your symptoms, cycle, menopause and earlier gynaecological findings, and on that basis assesses whether an endometrial sample should be taken. 

2. A brief gynaecological examination

A standard gynaecological examination is performed, and the gynaecologist gently positions a gynaecological instrument to examine the cervix. Duration 1-2 minutes. 

3. Taking the sample with a brush

A thin sterile brush is used to introduce through the cervix, and with a gentle rotation an endometrial sample is taken. Duration a few seconds. 

4. Sending for cytology

The sample is sent to the laboratory for cytological analysis. The findings are ready within a few days, after which a plan for the findings and follow-up is agreed.

Mild cramps similar to menstrual ones are possible; the intensity varies from person to person.
Light blood-tinged discharge is possible for a short time; you receive clear instructions on when to get in touch.

How to prepare?

  • If you have them, bring previous findings such as: an ultrasound finding of the endometrium, Pap/HPV, earlier histology/cytology.
  • Inform the doctor about the medicines you use, especially therapies that can affect bleeding (e.g. blood-thinning medicines).
  • If you have a cycle, give the date of your last period, as the appointment is sometimes adjusted to the phase of the cycle. 

Feel free to come with questions - the aim of the examination is for you to understand the procedure and the next steps.

Frequently asked questions before you arrive

  • Is anaesthesia needed?
    It is often done on an outpatient basis without anaesthesia. The procedure is short and most women feel only mild cramps. 
  • How long does the procedure take?
    As a rule a short time, a few minutes (depending on the examination and the indication).
  • Can I function normally after the procedure?
    Most often yes; in most cases you can return to everyday activities immediately. 
  • May I come if I have light bleeding? 
    In some cases yes, but it is best to check with the doctor. 
Note:We recommend a light meal and arriving with an empty bladder so that the examination is as comfortable as possible. 

What does the Uterobrush result show?

The aim is to obtain a sample of cells from the uterine lining (endometrium) in order to assess whether there are changes that require further diagnostics and treatment. It most often includes: 

1
A cytological finding of the endometrium
A finding that helps to assess whether there is a suspicion of hyperplasia, an inflammatory change or a suspicion of endometrial cancer.
2
An explanation of the findings in an understandable way
What the findings mean, whether the findings are normal and require further work-up, and what the realistic options going forward are.
3
A plan for the next steps
Depending on the findings, the plan may include: monitoring, treatment or additional diagnostics (e.g. hysteroscopy/biopsy) as indicated.

In practice this means

  • an explanation of the findings in an understandable way
  • a recommendation on what to do next and within what timeframe
  • an arranged follow-up (if needed) with a clear timeframe
  • clear instructions on when to get in touch earlier (e.g. heavier bleeding, pain)
Discreet
Clear
Fast

Why choose endometrial diagnostics at Cito Polyclinic?

In procedures like these, the most important things are that the procedure is safe, that you understand the findings and that you know what comes next. What you get: 

  • the examination is performed by a gynaecologist with experience in diagnosing endometrial changes 
  • a discreet and gentle approach
  • a clear explanation of the indication and expectations
  • a plan that does not end “with the findings” - but with concrete steps
  • the option to combine with a gynaecological examination and ultrasound (if needed)

Do you have abnormal bleeding or a finding of a thickened endometrium?

Get in touch - we will choose a targeted work-up and explain what we are doing and why.

Request an appointment FAQ

Price of the Uterobrush procedure

The price of taking a sample using the Uterobrush method at Cito Polyclinic is 100€. Please note that additional laboratory analyses or related gynaecological procedures are charged separately.

You can get the first available appointment straight away by phone on +385 21 457 800 or by sending a short message via the contact form.

  View the full price list

Doctors

Our team of expert physicians

Nađa Aračić
Doc.dr.sc.

Nađa Aračić, dr.med.

Specialist in Gynecology and Obstetrics

Subspecialist in Gynecological Endocrinology and Human Reproduction

Ante Mršić

Ante Mršić, dr.med.

Specialist in Gynecology and Obstetrics

Subspecialist in Gynecological Endocrinology and Human Reproduction

Petar Poljak

Petar Poljak, dr.med.

Specialist in Gynecology and Obstetrics

Subspecialist in Gynecological Endocrinology and Human Reproduction

Stipe Medvidović

Stipe Medvidović, dr.med

Specialist in Gynecology and Obstetrics

Zdravko Odak
Dr.sc.

Zdravko Odak, dr.med.

Specialist in Gynecology and Obstetrics

Frequently Asked Questions

Find answers to common questions about this service

What is Uterobrush and why is it used?

A special brush for endometrial sampling in the diagnosis of abnormal bleeding and assessment of hyperplasia.

How is the sample taken and is the procedure painful?

In the outpatient setting, without dilation, with brief discomfort similar to a menstrual cramp.

When does the result arrive and what do the results mean?

The cytological/cytohistological analysis is available in 7–14 days; the finding defines the need for further workup.

Are there risks or restrictions after sampling?

Rarely scant bleeding; tampons and intercourse should be avoided for 24–48 h.

Testimonials from our patients

Heartfelt praise for Polyclinic Cito! Pleasant, attentive, always available. The nurses are smiling, calm, full of support. From the very first moment you get a feeling of safety and professionalism. I would like to highlight Dr. Petar Poljak and Sisters Ivana and Lucija. I also commend the cleanliness of the entire polyclinic :) Here you don't feel like a patient, but like a friend :) Thank you to the whole team!🩵

Darija T

08.01.2026.
5/5

I read both positive and negative comments here and I wonder if we are going to the same polyclinic. I have only the best praise for Dr. Petar Poljak. I have been going there for three years and I don't know why I didn't write earlier. The doctor is so kind and relaxed. I used to always avoid male gynecologists, but now I would not go to a female one anymore because on several occasions male gynecologists have proven to be more professional and accommodating to me. Whenever I came, I never waited long. The last 2 times I came even earlier and they took me in right away. Really all the best about the doctor and the polyclinic responsible for gynecology - I have not used other branches of medicine with them, although I would gladly go if I needed to.

Dejana D

13.03.2025.
5/5

All recommendations for Dr. Mršić for his pleasantness, detailed examination and providing all possible information. Praise to the polyclinic for the good time management.

Ana P

06.06.2025.
5/5

All praise for the entire Polyclinic Cito, from Dr. Poljak to Dr. Aračić, all the way to the staff - Sister Janja, Sister Lucija... A kind word in difficult moments means a lot. Dr. Poljak is a great expert in his field; Dr. Aračić is kind, approachable and extremely thorough - in a word, all praise.

Ivana K

03.02.2026.
5/5

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