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Endometrial Aspiration (Pipelle)

Endometrial aspiration (histoaspiration) - taking a sample of the uterine lining for histopathology

Endometrial aspiration, often called histoaspiration, uses a short aspiration instrument (tube) to obtain a sample of the uterine lining (endometrium) for histopathological analysis. It is used when a more detailed finding is needed and when there is a stronger suspicion of endometrial changes. 

Page Overview

What is endometrial aspiration (histoaspiration)?

Endometrial aspiration is a method of sampling the endometrium (the uterine lining) with a thin instrument (an aspiration catheter) that is introduced through the cervix into the uterine cavity, and the tissue is collected by aspiration, i.e. gentle suction. The sample is sent for histopathological analysis (histology), which provides information about the structure of the tissue.

Note: Histoaspiration provides a tissue sample for histological analysis, but in some cases (e.g. suspicion of a polyp or the need for direct examination of the uterine cavity) additional diagnostics may be recommended, such as hysteroscopy - at the doctor's discretion.

What is assessed by this?

The state of the endometrium in situations such as:

  • irregular or heavy bleeding from the uterus 
  • bleeding after menopause
  • a finding of a thickened endometrium on ultrasound
  • suspicion of endometrial hyperplasia or other changes 
  • the diagnosis of infertility in some cases 

When is endometrial aspiration recommended?

It is done when a sample of the uterine lining (endometrium) needs to be taken for histological analysis and confirmation of the diagnosis. The most common indications: 

Abnormal bleeding

  • heavy or prolonged periods
  • bleeding between cycles
  • irregular bleeding in perimenopause
  • bleeding after intercourse (depending on the examination findings and cervical tests)

Menopause and postmenopause

  • any bleeding after menopause
  • a thickened endometrium on ultrasound when histological confirmation of changes is needed 

  • confirmation of suspected endometrial hyperplasia and other changes of the uterine lining

  • when an endometrial biopsy needs to be done to confirm the cause of the symptoms 

A quick decision: If you have bleeding after menopause, get in touch as soon as possible - this is always a reason for prompt assessment and targeted diagnostics.

What does histoaspiration look like?

The procedure is short and performed on an outpatient basis. The aim is to take a tissue sample of the uterine lining (endometrium), which is sent for histopathological analysis for an accurate diagnosis.

1. Conversation and indication

The gynaecologist talks with you about your symptoms,  previous findings and assesses whether an aspiration or biopsy is needed. 

2. Gynaecological examination

The procedure begins with a brief standard gynaecological examination, with a discreet and gentle approach. 

3. Endometrial aspiration

A thin instrument (a tube) is introduced through the cervix and, by aspiration, i.e. gentle suction, a small sample of endometrial tissue is taken. It takes a few seconds. 

4. Sending for histopathology

The tissue sample is sent to the laboratory for histological analysis. After the findings, we explain the result and what the next steps are.

Brief cramps similar to menstrual ones are possible; the intensity is individual. As we do so, we explain what we are doing and adjust the pace.
Light blood-tinged discharge is possible for a short time. You receive clear instructions on what is expected and when to get in touch.

How to prepare for histoaspiration?

  • Bring earlier findings: ultrasound of the endometrium, Pap/HPV, earlier histology/cytology (if any).
  • Inform the doctor about the medicines you take (especially if you take therapy that can affect bleeding).
  • If you have a cycle, give the date of your last period (the appointment is often adjusted to the indication).

If you feel fear/discomfort, tell us in advance - we will adapt the procedure to make it as comfortable as possible. 

Quick check before you arrive

  • Do I need to fast?
    As a rule no (unless we arrange additional tests in advance).
  • Is anaesthesia needed?
    The procedure is most often done on an outpatient basis without anaesthesia. If needed, local anaesthesia can be applied. 
  • Can I function normally after the procedure?
    Most often yes, with the instructions you receive on the spot.
Note:We recommend a light meal and relaxation, with a sanitary pad mandatory after the procedure..

What do you gain from the endometrial aspiration result?

The aim is to obtain a tissue sample of the uterine lining, which is analysed histopathologically for reliable further diagnostics and treatment. You receive: 

1
A histopathological finding of the endometrium
A finding that helps to confirm or rule out hyperplasia, pre-cancerous or malignant changes of the endometrium.
2
A clear explanation of the findings
What the findings mean, whether they are normal and whether there is a need for further work-up
3
A plan for the next steps
Depending on the findings, the plan may include monitoring, treatment (e.g. hysteroscopy/curettage) or additional diagnostics.

In practice this means

  • an explanation of the findings in an understandable way
  • a recommendation on what to do next and within what timeframe
  • an arranged follow-up (if needed) with a clear timeframe
  • clear instructions on when to get in touch earlier (e.g. heavier bleeding, more severe pain, a temperature)
Discreet
Clear
Fast

Why choose Cito Polyclinic?

In tests like these, the most important things are safety, clarity and a good plan after the findings. Our expert team provides you with: 

  • a discreet and gentle approach during the examination 
  • targeted indication of the test (without unnecessary steps)
  • a clear explanation of the procedure and the findings
  • a plan that includes monitoring and the next steps (it does not end “with the findings”)

Do you have abnormal bleeding or a finding of a thickened endometrium?

In such situations it is important to assess the state of the uterine lining in good time. Get in touch - we will choose a targeted work-up and explain what we are doing and why.

Request an appointment FAQ

Price of endometrial aspiration (histoaspiration)  

The price of the procedure at Cito Polyclinic is 100€. Please note that additional laboratory analyses or related gynaecological procedures are charged separately. 

You can get the first available appointment straight away by phone on +385 21 457 800 or by sending a short message via the contact form.

  View the full price list

Doctors

Our team of expert physicians

Nađa Aračić
Doc.dr.sc.

Nađa Aračić, dr.med.

Specialist in Gynecology and Obstetrics

Subspecialist in Gynecological Endocrinology and Human Reproduction

Ante Mršić

Ante Mršić, dr.med.

Specialist in Gynecology and Obstetrics

Subspecialist in Gynecological Endocrinology and Human Reproduction

Petar Poljak

Petar Poljak, dr.med.

Specialist in Gynecology and Obstetrics

Subspecialist in Gynecological Endocrinology and Human Reproduction

Stipe Medvidović

Stipe Medvidović, dr.med

Specialist in Gynecology and Obstetrics

Zdravko Odak
Dr.sc.

Zdravko Odak, dr.med.

Specialist in Gynecology and Obstetrics

Frequently Asked Questions

Find answers to common questions about this service

In which situations is endometrial aspiration performed and what does it detect?

For abnormal bleeding, suspected endometrial hyperplasia/carcinoma or monitoring of hormonal therapy.

How is the procedure performed and how long does it last?

Outpatient with a thin catheter (pipelle) under negative pressure; the procedure takes a few minutes.

Is anesthesia required and will it hurt?

Usually not required; brief cramping is possible and can be relieved with an analgesic.

When will I receive the results and what if they are abnormal?

The finding is available in 7–14 days; abnormal results require further diagnostics (hysteroscopy, D&C) per guidelines.

Testimonials from our patients

Heartfelt praise for Polyclinic Cito! Pleasant, attentive, always available. The nurses are smiling, calm, full of support. From the very first moment you get a feeling of safety and professionalism. I would like to highlight Dr. Petar Poljak and Sisters Ivana and Lucija. I also commend the cleanliness of the entire polyclinic :) Here you don't feel like a patient, but like a friend :) Thank you to the whole team!🩵

Darija T

08.01.2026.
5/5

I read both positive and negative comments here and I wonder if we are going to the same polyclinic. I have only the best praise for Dr. Petar Poljak. I have been going there for three years and I don't know why I didn't write earlier. The doctor is so kind and relaxed. I used to always avoid male gynecologists, but now I would not go to a female one anymore because on several occasions male gynecologists have proven to be more professional and accommodating to me. Whenever I came, I never waited long. The last 2 times I came even earlier and they took me in right away. Really all the best about the doctor and the polyclinic responsible for gynecology - I have not used other branches of medicine with them, although I would gladly go if I needed to.

Dejana D

13.03.2025.
5/5

All recommendations for Dr. Mršić for his pleasantness, detailed examination and providing all possible information. Praise to the polyclinic for the good time management.

Ana P

06.06.2025.
5/5

All praise for the entire Polyclinic Cito, from Dr. Poljak to Dr. Aračić, all the way to the staff - Sister Janja, Sister Lucija... A kind word in difficult moments means a lot. Dr. Poljak is a great expert in his field; Dr. Aračić is kind, approachable and extremely thorough - in a word, all praise.

Ivana K

03.02.2026.
5/5

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